It was, until recently, accepted that the two classes of acetylcholine (ACh) receptors are distinct in an important sense: muscarinic ACh receptors signal via heterotrimeric GTP binding proteins (G proteins), whereas nicotinic ACh receptors (nAChRs) open to allow flux of Na+, Ca2+, and K+ ions into the cell after activation. Here we present evidence of direct coupling between G proteins and nAChRs in neurons. Based on proteomic, biophysical, and functional evidence, we hypothesize that binding to G proteins modulates the activity (...) and signaling of nAChRs in cells. It is important to note that while this hypothesis is new for the nAChR, it is consistent with known interactions between G proteins and structurally related ligand‐gated ion channels. Therefore, it underscores an evolutionarily conserved metabotropic mechanism of G protein signaling via nAChR channels.Also watch the Video Abstract. (shrink)

Der Beitrag beschäftigt sich mit Husserls Lehre von der kategorialen An­schauung als einem der wichtigsten Momente seines Versuchs der Grund­legung der Phänomenologie als eidetischer Wissenschaft. Ausgehend von Husserls phänomenologischen Kritik an Versuchen einer Naturalisierung des Bewusstseins, werden insbesondere die Probleme der Bedeutungs­intention und -erfüllung, des Unterschieds zwischen sinnlicher und kate­gorialer Anschauung, der kategorialen Formung und der sog. Wesens­anschauung erörtert. In diesem Zusammenhang geht es auch um die Abgrenzung des Husserlschen transzendentalphilosophischen Ansatzes von der transzendentalphilosophischen Axiomatik Immanuel Kants.

Many species maintain cytosine DNA methyltransferase (MTase) genes belonging to the Dnmt2 family. Prokaryotic modification‐restriction systems utilize DNA methylation to distinguish between self and foreign DNA, and cytosine methylation in eukaryotic DNA contributes to epigenetic mechanisms that control gene expression. However, Dnmt2 proteins display only low or no DNA MTase activity, making this protein family the odd and enigmatic family member. Recent evidence showed that Dnmt2 proteins are not DNA but RNA MTases with functions in biological processes as diverse as (...) stress responses and RNA‐mediated inheritance. These observations not only raise profound questions regarding the perceived substrate specificities of cytosine MTase, but also suggest links between DNA and RNA modification systems. Here, we speculate that Dnmt2 proteins might be part of an ancient cytosine modification toolbox that is used to successfully respond to environmental challenges, including constantly evolving RNA and DNA substrates. (shrink)

De Interpretatione is among Aristotle's most influential and widely read writings; C. W. A. Whitaker presents the first systematic study of this work, and offers a radical new view of its aims, its structure, and its place in Aristotle's system. He shows that De Interpretatione is not a disjointed essay on ill-connected subjects, as traditionally thought, but a highly organized and systematic treatise on logic, argument, and dialectic.

Više začuđuje da je Aristip, koji se smatra rodonačelnikom kirenskog hedonizma, sokratovac, nego činjenica da je rodom iz mediteranske Kirene. Grad u kome je rođen, osnovali su nekoliko stoljeća prije grčki koloni, koji su došli s otoka Tere. Po Pindaru, njegova je porodica bila najbogatija i najuzvišenijeg roda u cijeloj Libiji, čime se objašnjava činjenica što je budući hedonist, od malena, bio naviknut na život u raskoši. Nikada ga nisu smatrali sokratovcem u pravom smislu te riječi , što će biti (...) razlogom spora među Sokratovim sljedbenicima. Svijet čulne realnosti kojem je on pripadao, s jedne strane, te Platonov idealni, s druge, implicira pitanje Sokratova izvornog učenja: hedonistički, kirenski ili onaj platonizirani Sokrat, kako sugerira najveći broj istraživača?The fact that Aristippus, considered the founding father of Cyrenaic hedonism, is a Socratic is far more astounding than the fact that he was born in Cyrene on the Mediterranean. His hometown was founded a few centuries earlier by Greek colonists arriving from the Island of Thera. According to Pindar, his family was the richest and of the noblest lineage in the whole of Libya, which says that this future hedonist had been used to a life in luxury ever since he was born. He was never considered a Socratic in the true sense of the word , which was to become the cause of controversy between Socrates’s followers. The world of sensual reality he belonged to on the one hand and Plato’s world of ideas on the other pose the question of Socrates’s original orientation – was he originally a hedonist, a Cyrenaic or a Platonist, which is what most researchers suggest? (shrink)

The authors present a case study involving truth telling responsibilities in the setting of nonepileptic seizures. Specifically, over the course of several suspected nonepileptic seizures, a patient’s seizures stopped after he received a saline flush meant to precede the administration of anti-seizure medication. The patient and his surrogate believed he had received the medication each time, and the team wondered whether they should disclose the truth. Some worried that disclosure would reinforce the suspected psychogenic behavior, exacerbating the patient’s condition. In (...) this way, the case study presents a twist on the traditional truth telling archetype. While most truth telling cases center on navigating cultural differences or worries about emotional harm, this case presented concerns about medical harm in the form of exacerbating the patient’s condition. The authors describe the complex patient-family-team dynamic that preceded this ethical dilemma, describe the case, analyze the ethical issue, and describe the outcome. (shrink)

Starting from Wilhelm Dilthey?s concept of understanding, the article inquires into modes of forming competencies within the experience of reflexive education. In line with moder?nity?s understanding of science, the text designates the role of sciences as instances of po?ssible real values, whereby the spiritual sciences are ascribed the role of giving meaning by broadening horizons. The article questions the ground that allows for spiritual and pedagogical sciences within the commercialization of university teaching and research activities. In all this, functionalization conducts (...) a process leading to the weakening of the constructive role of these sciences in the formation of competencies. (shrink)

Heideggersche erste Bewegungen in Richtung auf die Funda?mentalontologie lassen sich in seinen Vorlesungen der fr?hen 20er Jahren beobachten. Heidegger versucht darin, sich von dem Logizismus der Husserlschen Bewusstseinsphilosophie zu emanzipieren, indem er ein Konzept der Urwissenschaft entwirft. Die Urwis?senschaft soll bei der vortheoretischen Erfahrung, d. h. bei den vorreflexiven Erlebnissen ansetzen. Sie hat der entlebenden Tendenz der theoretischen Einstellung zum Erlebnis?strom entgegenzuwirken und somit die Voraussetzungen daf?r zu schaffen, eine Viel?falt der lebendigen Erfahrungsweisen zum ausdr?cklichen Verstehen zu bringen. Somit kn?pft (...) die Urwissenschaft an das Programm der Ph?nomenologie von Edmund Husserl, modifiziert es aber entscheidend, indem es aus der Sph?re des Bewusstseins in jene des lebendigen Erlebnisstroms verlegt. Hajdegerovi prvi pomaci u pravcu fundamentalne ontologije mogu se posmatrati u njegovim predavanjima iz dvadesetih godina proslog veka. U njima Hajdeger pokusava da se emancipuje od logicizma Huserlove filozofije svesti tako sto razvija projekat pranauke. Ona treba da krene od predteoretskog iskustva, tj. predrefleksivnih dozivljaja. Pranauka treba da deluje nasuprot obezivotljavajucoj tendenciji teoretskog stava spram toka dozivljaja te tako stvori pretpostavke za izricito razumevanje visestrukosti zivotnih nacina iskustva. Pranauka se time nadovezuje na program fenomenologije Edmunda Huserla, ali ga modifikuje na odlucujuci nacin tako sto ga premesta iz sfere svesti u sferu zivotnog toka dozivljaja. (shrink)

Der Beitrag beschäftigt sich mit Husserls Lehre von der kategorialen An­schauung als einem der wichtigsten Momente seines Versuchs der Grund­legung der Phänomenologie als eidetischer Wissenschaft. Ausgehend von Husserls phänomenologischen Kritik an Versuchen einer Naturalisierung des Bewusstseins, werden insbesondere die Probleme der Bedeutungs­intention und -erfüllung, des Unterschieds zwischen sinnlicher und kate­gorialer Anschauung, der kategorialen Formung und der sog. Wesens­anschauung erörtert. In diesem Zusammenhang geht es auch um die Abgrenzung des Husserlschen transzendentalphilosophischen Ansatzes von der transzendentalphilosophischen Axiomatik Immanuel Kants.

Der Beitrag besch?ftigt sich mit dem Verh?ltnis von Hermeneutik und Ethik. Im Fokus dieser Betrachtung steht die narrative Hermeneutik des Selbst von Paul Ricoeur und ihr Versuch, mit Hilfe der Hermeneutik eine ethische Dimension der Wiedereinschreibung der narrativen Rekonfiguration der Handlungswelt in diese Handlungswelt selbst zu er?ffnen. Dabei wird auf die Grenzen eines solchen Ansatzes hingewiesen, dies insbesondere im Hinblick auf die dabei gemachten metaphysiklastigen Schritte in Richtung auf eine Position, die hinter der existential- und fundamentalontologischen Fragestellung des von Ricoeur (...) kritisierten Heidegger zur?ckzufallen scheint. Daher wird hier erneut auf Heidegger und seine Existenzialontologie zur?ckgegriffen, um sie im Zuge einer narrativistischen Umdeutung f?r die ethische Fragestelleung zu?ffnen. (shrink)

Der Beitrag thematisiert vor allem unterschiedliche philosophische Auffasungen der Andersheit und versucht, sie aus einer hermeneutischen Perspektive zu hinterfragen. Dabei wird vor allem die konzeptuelle Radikalität der assymetrischen Beziehungen kritisiert, indem der hermeneutische Ansatz nicht als bloße Aneignungs- strategie des Anderen oder Fremden aufgefasst wird, sondern als offener Prozess der Verständigung, in dem die Heterogenität der Verständigungs- akteure zwar einer ständiger Veränderung unterzogen, jedoch immer auch gewahrt wird. Davon ausgehend wird auch die kulturphilosophische, aber auch gesellschaftliche und politische Relevanz der (...) Opposition zwischen Kulturpessimismus und Kulturoptimismus in Frage gestellt. (shrink)

The article primarily addresses different philosophical views of otherness and tries to question them from a hermeneutic perspective. Above all, the conceptual radicalism of the asymmetrical relationships is criticized through the hermeneutic approach, understood not as mere strategy of appropriating the other or the stranger, but as an open process of understanding, in which the heterogeneity of those involved is subject to constant change, but is nevertheless always maintained. On this basis, the cultural-philosophical, but also social and political relevance of (...) the opposition between cultural pessimism and cultural optimism is called into question. (shrink)

Der Beitrag beschäftigt sich mit der Kritik an der Philosophie von Ludwig Klages, die in den 1920-ern Jahren seine Zeitgenossen wie Helmuth Plessner, Georg Misch und etwas später in den 1930-ern Jahren auch Max Bense übten. Der Gegenstand der Kritik war vor allem seine These von der grundlegenden Opposition von Geist und Seele aber auch seine graphologischen Schriften. Im Zentrum der hier vorgelegten Analyse steht die Herausarbeitung der Inkongruenz dieser kritischen Stimmen, die sich darauf bezieht, dass Klages sowohl den naturalistischen (...) als auch irrationalistischen Vorwürfen ausgesetz ist. (shrink)

Tekst najpre ispituje u kojoj meri se kod ranog Hajdegera da primjetiti pomeranje tezista sa okolosvetskog karaktera dozivljaja na?fakticki? tubivstvujuci zivot odnosno na fenomen?Ja sam?. Treba da se zahvati smisao bica toga?Ja sam? i to tako sto ce se odrediti razlika samoiskustva i refleksivno-teoretskog stava. Ovo odredjenje treba drzati podalje od svih regionalnih i stvarskih stranosti. Individuacija onog?Ja sam? ne treba da se zahvati kao opojedinacenje u pogledu na neko opsto, nego kao povesno opojedinacenje. Smisao bica kao smisao egzistencije treba (...) da se zahvati u samoiskustvu i ima smisao sprovodjenja. Osnovno iskustvo sopstva odnosno povesnosti karaktera sprovodjenja sopstva stavice se u novi utemeljujuci odnos spram apriornosti. Pri tome centralna uloga pripada destrukciji istorijskog horizonta problema apriornosti, a pod cim treba da se razumije radikalizacija fenomenologije koja uvijek iznova pokusava da svoju povesnost odnosno povesnu situaciju sprovede sto izvornije. Razjasnice se sadrzajna struktura problema apriornosti tako sto ce se odrediti povest shvatanja apriorija prema stepenu njihove tubicevne imanentnosti. Destrukcija problema apriorija ce se pokusati na rekonstruktivnoj psihologiji Paula Natorpa i kritici povesne svesti Vilhelma Diltaja pri cemu im se prebacuje postvarenje sfere zivoga. (shrink)

The main aim of shamanic initiation among the Yanomami people of the Upper Orinoco River region in Venezuela is the metamorphosis of the human body into a cosmic body, or what I term "corporeal cosmogenesis." During the initiatory ordeal, the neophyte undergoes an intense experience of death through dismemberment by the spirits and subsequent rebirth, thus overcoming the human condition and becoming an individual living spirit. But, at the same time, he becomes a "collection" of other spirits who leave their (...) natural habitats—located on the mountaintops and in the forest—and move into the initiate's body, which becomes their abode. As the candidate surrenders his soul and humanness to the spirits, the latter become his personal allies and sources of power while imbuing the shaman's postmortem ego with certain properties that can best be described in holographic terms. After the shaman's biological death, his personal spirits become disembodied again and disperse back into the forest and on the mountaintops. When the shaman dies, his soul multiplies, as each of the disembodied spirits becomes a carrier of the shaman's soul image. In this way, through initiations, the shaman becomes a part of a dynamic cosmic circuity, as his hekura can be called upon to invade the bodies of new shamans, and start a cosmogonic initiatory act anew. (shrink)

Significant breakthroughs in genetic research promoted by the human genome project, advances in molecular biology and new reproductive technologies have improved the understanding and the possibility of genetic interventions as a potential medication for diseases caused by differentiated disorders, especially those that originated in irregularities in individual genes. The progress achieved in contemporary studies has created the likelihood that the man has the technical capacity to modify the genes that will be transmitted to the next generations as well. These are (...) the so-called hereditary genetic modifications, i.e. any biomedical interventions which could be expected to transform the genome which a person could transfer to their offspring. The author analyses in this paper why even the hints of transformations of genes that will be passed on to future generations cause deep bioethical, theological, legal and political debates and controversies. He also believes that in the era of rapid strengthening of the social and technical and technological effects of science, it is very important that scientists, in their perceptions and insights, which particularly in the field of humanities, do not have the character of value beliefs, do not go below the achieved civilization standards of ethical and moral culture and to reflect on different themes with due care and awareness of the dilemmas that they can encounter in their professional work. An adequate interdisciplinary, multidisciplinary and pluriperspective approach, as well as the awareness of the essential compatibility of scientific freedom and responsibility, should ultimately result in a different and more sophisticated attitude of the scientists themselves to the possibilities of their own discipline and the significance of its effects. (shrink)

Both Carnap and Quine made significant contributions to the philosophy of mathematics despite their diversedviews. Carnap endorsed the dichotomy between analytic and synthetic knowledge and classified certainmathematical questions as internal questions appealing to logic and convention. On the contrary, Quine wasopposed to the analytic-synthetic distinction and promoted a holistic view of scientific inquiry. The purpose of thispaper is to argue that in light of the recent advancement of experimental mathematics such as Monte Carlosimulations, limiting mathematical inquiry to the domain of (...) logic is unjustified. Robustness studies implemented inMonte Carlo Studies demonstrate that mathematics is on par with other experimental-based sciences. (shrink)

Postcolonial science studies entails ostensibly contradictory critical and empirical commitments. Science studies scholars influenced by Bruno Latour and Isabelle Stengers embrace forms of realist, radical empiricism, while postcolonial studies scholars influenced by Jacques Derrida trace the limits of the knowable. This essay takes their common use of the term cosmopolitics as an unexpected point of departure for reconciling Derrida’s program with Stengers’s and Latour’s. I read Derrida’s critique of hospitality and Stengers’s and Latour’s ontological politics as necessary complements for conceiving (...) a care-oriented subalternist cosmopolitics, a process of composing common worlds that remains attentive to the limits of representation. (shrink)

Do famous athletes have special obligations to act virtuously? A number of philosophers have investigated this question by examining whether famous athletes are subject to special role model obligations (Wellman 2003; Feezel 2005; Spurgin 2012). In this paper we will take a different approach and give a positive response to this question by arguing for the position that sport and gaming celebrities are ‘ambassadors of the game’: moral agents whose vocations as rule-followers have unique implications for their non-lusory lives. According (...) to this idea, the actions of a game’s players and other stakeholders—especially the actions of its stars—directly affect the value of the game itself, a fact which generates additional moral reasons to behave in a virtuous manner. We will begin by explaining the three main positions one may take with respect to the question: moral exceptionalism, moral generalism, and moral exemplarism. We will argue that no convincing case for moral exemplarism has thus far been made, which gives us reason to look for new ways to defend this position. We then provide our own ‘ambassadors of the game’ account and argue that it gives us good reason to think that sport and game celebrities are subject to special obligations to act virtuously. (shrink)

O presente artigo apresenta três teses principais. A primeira diz que, nos Seminários de Zollikon, Heidegger desenvolveu projeto de uma antropologia, patologia e terapia daseinsanalíticas no qual ele rejeita a metapsicologia de Freud, mas preserva suas descobertas fatuais e procedimentos de cura. A secunda tese sustenta que Winnicott introduziu um novo paradigma na psicanálise que igualmente rejeita a metapsicologia freudiana e centra a pesquisa e a cura psicanalíticas sobre problemas de amadurecimento pessoal e não mais sobre o complexo de Édipo. (...) A terceira tese combina as duas primeira para dizer a) que a psicanálise winnicottiana satisfaz os requisitos de Heidegger para a patologia e a terapia daseinsanalíticas, b) que, além disso, essa nova psicanálise pode estimular de maneira decisiva a pesquisa futura no campo da antropologia daseinsanalítica.The paper proposes three main theses. The first thesis says that in Zollikoner Seminare Heidegger has developed a project of a daseinsanalytic anthropology and pathology in which he rejects Freud's metapsychology, but accepts his factual findings and therapeutic procedures. The second thesis affirms that Winnicott has introduced a new paradigm in psychoanalysis which also rejects Freud's metapsychology and centers the psychoanalytic research and therapy on the problem of maturation and no more on the Oedipus Complex. The third thesis combines the first two in saying a) that Winnicott's psychoanalysis satisfies Heidegger's requirements for a daseinsanalytic pathology and therapy and b) that, moreover, it can stimulate, in a decisive manner, the future research in the field of daseinsanalytic anthropology. (shrink)

Croatian literary culture of the 18th century is marked by stylistic pluralism, considering that its Enlightenment character and its didactic and utilitaristic dimensions are emphasized the most. Austrian catechism was the fundamental book of school religious education from 1777 until 1847 in the whole Habsburg Monarchy, and it played an important role in the upbringing of children, but also of the entire family and social community in the spirit of Josephine politics. This topic is viewed from the perspective of Immanuel (...) Kant who found it important to emphasise the dangers to which the fetishisation of ecclesiastical norms can lead to, i.e. to hinder the development of critical moments of liberty and upbringing. The absence of Enlightenment period in Croatian countries of the Habsburg Monarchy is complexly conditioned: from religious resistance and changes in a social and political sense to stagnancy and lack of education of a large part of the population, altogether favourable to the Croatian nobility and clergy. (shrink)

O presente estudo propõe-se reconstruir o conceito winnicottiano da unidade psicossomática do ser humano. Depois de expor o caráter acontecencial e a estrutura interna do psique-soma, oferece uma análise detalhada das operações da "elaboração imaginativa", começando pela tentativa de definir a natureza dessas operações. Prossegue com o exame das operações mais primitivas que garantem a inter-relação inicial básica da psique e do soma, chama a atenção para a constituição do si-mesmo imaginativo, e termina identificando e explicando algumas operações elaborativas mais (...) avançadas, assumidas pelos indivíduos humanos sadios "em primeira pessoa".The present study aims at reconstructing Winnicott's concept of psycho-somatic unity of the human being. After explaining the historical character and inner structure of the psyque-soma, it starts a detailed analysis of "imaginative elaboration" with an attempt to define the very nature of these operations. It examines next the most primitive of them that which elaborate the body functions thus garantee the initial psyche-soma relation, goes over to the problem of constitution of the imaginative self and ends by identifying and explaing some more advanced operations, assumed by grown up healthy indivuals "in the first person". (shrink)

An examination of David Hume's philosophy of religion that situates his conception "true religion" within the context of his overall science of human nature, his rejection of popular religion, and his Ciceronian influence"--Provided by publisher.